SGC-UNC is contributing chemical tools and NanoBRET assays to the IDG Drug and Resource Generation Center for Kinases led by Gary Johnson.
IDG Chemical Tools are cell active inhibitors for dark kinases on the IDG target list. Each inhibitor shows IC50 < 1 µM in a NanoBRET assay for its target dark kinase and also demonstrates a narrow spectrum of activity across a large panel of kinases (S10 < 0.05 at 1 µM).
The current list of IDG chemical tools with links to their supporting data is available on the Dark Kinase Knowledgebase.
Chemical tools that are not commercially available can be requested from the SGC-UNC.